I'm sure there are some I'm forgetting, even many scenarios I've yet to encounter: I've right clicked a fishing net for 14k at an in game shop, thinking it would allow me to compare to my current one, or at least prompt me before finalizing purchase as it has done every time I shop on GM. Now I have a bound fishing net that can't be traded or used on another civ, and is worse than the one I have equipped. I have changed crafting school, clicking on the wrong one to forget by mistake, losing an epic consumable recipe in the process. I don't know if the gear recipes disappear into the void too; thankfully, I didn't have any yet. I have sold items to the shop by mistake, but there is an undo buy option, so I became comfortable moving quickly in my inventory, especially when selling items. I also open chests quickly, usually quite a brain-dead task for me now that I hit lv 40 and it's mostly useless stuff. However, to my horror and joy, I recently double-clicked a chest recently as I was quickly right-clicking chests in my inventory to open them. One right click registered as opening the chest, the second as adding the advisor that was in it. It was a common advisor, and if it were to replace one of my epics, I'd probably cry a little. I was so happy to see the message saying the adovisor wasn't for my civ, realizing that something almost went terribly wrong. This game is fun, and it's awesome that it's free to play. Even paid games aren't perfect. Honestly the item management is pretty smooth once you've played for a while. You'll find yourself navigating, selling, buying, moving things around, and much more very quickly. However, there may be accidents; and while I can't discourage you from managing your items, sales, and trades quickly I'll say this: Click carefully my friends.